1. Khan, A. H.; Phan, C.-S. Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024. Front. Nat. Prod. 2025, 4. https://doi.org/10.3389/fntpr.2025.1616031

2. Khan, A. H.; Haedar, J. R.; Kiselov, V.; Romanuks, V.; Smits, G.; Donadio, S.; Phan, C.-S. P450 biarylitide synthase ShyB catalyzes cross-link between His-C2 and Tyr-O4 on the precursor peptide. Org. Lett. 2025, 27, 5715. https://pubs.acs.org/doi/10.1021/acs.orglett.5c01487

3. Khan, A. H.; Haedar, J. R.; Zīle, A.; Phan, C.-S. Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs. Tetrahedron Chem. 2025, 14, 10012. https://doi.org/10.1016/j.tchem.2025.100128

4. Khan, A. H.; Haedar, J. R.; Kiselov, V.; Romanuks, V.; Smits, G.; Donadio, S.; Phan, C.-S. Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide. ACS Chem. Biol. 2025, 20, 259. https://doi.org/10.1021/acschembio.4c00693

5. Haedar, J. R.; Khan, A. H.; Zīle, A.; Phan, C.-S. The Advancement of Peptides Derived from Kitasatospora. Chem. Biodivers. 2024, e202402999. https://doi.org/10.1002/cbdv.202402999

6. Zdouc, M. M. et al. MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Res. 2024, 53, 1. https://doi.org/10.1093/nar/gkae1115

7. Phan, C.-S., Morinaka, B. I. Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. RSC Chem. Biol. 2024, 5, 1195. https://doi.org/10.1039/D4CB00227J

Workshops

Workshop on June 13, 2025
Enzymes in Natural Products Biosynthesis

09:30 – 09:50 Welcome and introduction by Stefano Donadio and Chin-Soon Phan.
09:50 – 10:40 A Dual-Enzyme Dance: Radical SAM and Oxygenase Unite for Triceptide Formation by Yvain Nicolet, University Grenoble Alpes.
10:40 – 11:10 Coffee break.
11:00 – 12:00 Enzymatic Tailoring and Bioengineering of Aromatic Polyketides by Robin Teufel, University of Basel.
12:00 – 13:30 Lunch.
13:30 – 14:20 Bacteria as Tunable Drug Production Factories by Joleen Masschelein, KU Leuven.
14:20 – 14:50 Coffee break.
14:50 – 15:40 Expanding the Prenylated Ribosomal Peptide Diversity by Florian Hubrich, Helmholtz Institute for Pharmaceutical Research Saarland Saarland University.
15:40 – 16:15 Closing remarks and networking.

Workshop on October 30, 2024
Bioinformatics and evolutionary study in microbial natural products research

09:30 – 09:50 Welcome and introduction by Stefano Donadio and Chin-Soon Phan.
09:50 – 10:40 The molecular treasure hunt – mining genomic data for novel bioactives by Tilmann Weber, Technical University of Denmark.
10:40 – 11:10 Coffee break.
11:00 – 12:00 Computational omics to predict natural product structures and functions by Marnix H. Medema, Wageningen University.
12:00 – 13:30 Lunch.
13:30 – 14:20 Discovery and biosynthesis of non-canonical natural products by Lena Barra, University of Konstanz.
14:20 – 14:50 Coffee break.
14:50 – 15:40 Gene conversion drives natural product diversification in soil bacteria by Aleks Nivina, University of Zurich.
15:40 – 16:15 Closing remarks and networking.