1. Khan, A. H.; Haedar, J. R.; Zīle, A.; Phan, C.-S. Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs. Tetrahedron Chem. 2025, 14. https://doi.org/10.1016/j.tchem.2025.100128

2. Khan, A. H.; Haedar, J. R.; Kiselov, V.; Romanuks, V.; Smits, G.; Donadio, S.; Phan, C.-S. Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide. ACS Chem. Biol. 2025, 20, 259–265. https://doi.org/10.1021/acschembio.4c00693

3. Haedar, J. R.; Khan, A. H.; Zīle, A.; Phan, C.-S. The Advancement of Peptides Derived from Kitasatospora. Chem. Biodivers. 2024, e202402999. https://doi.org/10.1002/cbdv.202402999

4. Zdouc, M. M. et al. MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Res. 2024, 53, 1–13. https://doi.org/10.1093/nar/gkae1115

5. Phan, C.-S., Morinaka, B. I. Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. RSC Chem. Biol. 2024, 5, 1195–1200. https://doi.org/10.1039/D4CB00227J

Workshops

Workshop on October 30, 2024
Bioinformatics and evolutionary study in microbial natural products research

09:30 – 09:50 Welcome and introduction by Stefano Donadio and Chin-Soon Phan.
09:50 – 10:40 The molecular treasure hunt – mining genomic data for novel bioactives by Tilmann Weber, Technical University of Denmark.
10:40 – 11:10 Coffee break.
11:00 – 12:00 Computational omics to predict natural product structures and functions by Marnix H. Medema, Wageningen University.
12:00 – 13:30 Lunch.
13:30 – 14:20 Discovery and biosynthesis of non-canonical natural products by Lena Barra, University of Konstanz.
14:20 – 14:50 Coffee break.
14:50 – 15:40 Gene conversion drives natural product diversification in soil bacteria by Aleks Nivina, University of Zurich.
15:40 – 16:15 Closing remarks and networking.